Elastosis-a form of solar aging = المران كشكل من شيخوخة الجلدالضيائية |
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Features of Photoaged Skina
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CLINICAL
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HISTOLOGIC
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Dryness (roughness)
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Increased compaction of stratum corneum, increased thickness of granular cell layer, reduced epidermal thickness, reduced epidermal mucin content
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Actinic keratoses
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Nuclear atypia, loss of orderly, progressive keratinocyte maturation; irregular epidermal hyperplasia and/or hypoplasia; occasional dermal inflammation
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Irregular pigmentation
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Freckling
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Reduced or increased number of hypertrophic, strongly DOPA-positive melanocytes
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Lentigines
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Elongation of epidermal rete ridges; increases in number and melanization of melanocytes
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Guttate hypomelanosis
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Reduced number of atypical melanocytes
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Diffuse irreversible hyperpigmentation
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Increased number of DOPA-positive melanocytes and increased melanin content per unit area and increased number of dermal melanophages
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Wrinkling
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Fine surface lines
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None detected
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Deep furrows
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Contraction of septae in the subcutaneous fat
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Stellate pseudoscars (see eFig. 108-4.3 in on-line edition)
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Absence of epidermal pigmentation, altered fragmented dermal collagen
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Elastosis (fine nodularity and/or coarseness)
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Nodular aggregations of fibrous to amorphous material in the papillary dermis
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Inelasticity
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Elastotic dermis
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Telangiectasia
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Ectatic vessels often with atrophic walls
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Venous lakes
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Ectatic vessels often with atrophic walls
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Purpura (easy bruising)
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Extravasated erythrocytes and increased perivascular inflammation
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Comedones
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Ectasia of the pilosebaceous follicular orifice
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Sebaceous hyperplasia
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Concentric hyperplasia of sebaceous glands
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aBasal cell carcinoma and squamous cell carcinoma also occur in photoaged skin but, unlike the table entries, affect only a minority of individuals.
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