Balanoposthitis=التهاب القلفة والحشفة |
Balanoposthitis
Defined as the inflammation of the foreskin and glans in uncircumcised males, balanoposthitis occurs over a wide age range and may have any of multiple bacterial or fungal origins or be caused by contact dermatitides. Complex infections have been well documented, often from a poorly retractile foreskin and poor hygiene that leads to colonization and overgrowth. Treatment focuses on clearing the acute infection and preventing recurrent inflammation/infection through improved hygiene. Although not as necessary as in the past, circumcision may be considered for refractory or recurrent balanoposthitis. Balanoposthitis should not be confused with balanitis, which is inflammation of the glans penis or the clitoris.
PathophysiologyAlthough multiple organisms have been incriminated as causative agents, the patient is empirically treated without obtaining specific organism etiology in most cases. The multicausal origin of balanoposthitis has been emphasized by Fornasa et al, who identified infectious, mechanical/traumatic, or contact dermatitides in 67% of their patients with balanoposthitis.1 In one third of the patients, a specific cause could not be established even after clinical examination and microbiologic and serologic tests had been performed. Candidal infection appears to be the most common cause of disease. Older men often have other etiologies, including intertrigo, irritant dermatitides, or other fungal infections. Organisms that have been identified include Bacteroides, Gardnerella,2,3 and Candida species and beta-hemolytic streptococci. Mayser has proposed that candidal balanitis/balanoposthitis is the most frequent mycotic infection of the penis,4 although, in general, fungal infections of the penis are rare. In one series, Candida species accounted for 30% of the causative organisms, and beta-hemolytic streptococci accounted for 13%. Wakatsuki detected the following infectious agents as a cause: Candida species in 50%, Streptococcus species in 25%, and no growth in 13% (12% were not tested).5 Rare causes include Streptococcus pyogenes,6 Prevotella melaninogenica, Cordylobia anthropophaga,7 Providencia stuartii, and Pseudomonas aeruginosa, the last 2 in individuals who are immunocompromised. Reports of an association between human papillomavirus (HPV) infection and long-standing balanoposthitis have been published, but they may reflect a noncausative association.8,9,10 Associations with ulcerative colitis11 and Crohn disease12 have also been noted. A case of granulomatous balanoposthitis after intravesical BCG vaccine instillation therapy has been published.13
HistoryIn adults, a detailed clinical history focusing on topical irritants and home remedies assists in making the correct diagnosis and in detecting possible contact dermatitides. Physical
CausesIn a study conducted by Alsterholm et al, patients with balanoposthitis had a significantly higher frequency of positive cultures than in the control group (59% and 35%, respectively, P <.05).20 In the balanoposthitis group, Staphylococcus aureus was found in 19%, group B streptococci in 9%, Candida albicans in 18%, and Malassezia in 23% of patients. In the control group, S aureus was not found at all, whereas C albicans was found in 7.7% and Malassezia in 23% of patients. Different microbes did not correspond with distinct clinical manifestations.Although not shown to be a direct cause, an association exists between nonspecific balanoposthitis and the uncircumcised penis. Mallon et al have proposed that circumcision may protect against balanoposthitis and common penile infections.21 Rare causes include a contact-induced balanoposthitis from the application of celandine juice (from the plant Chelidonium majus). An association with preputial smegma stones has been described, a correlation that most likely reflects the hygiene of the affected population
Other Problems to Be ConsideredCandidal, viral, or fungal infections
Laboratory Studies
Imaging Studies
Other Tests
Procedures
Histologic FindingsThe histologic findings are nonspecific and eczematous in nature. Dermis contains lymphoplasmacytic infiltrates. Special stains for fungi, such as the periodic acid-Schiff (PAS) stain, may exhibit fungal elements characteristic of candidal organisms.
Medical Care
Surgical CareCircumcision may be advocated in recurrent and recalcitrant cases. MedicationTopical medications are the treatment of choice in this condition. The primary goal is elimination of various pathogenic organisms and control of inflammation. AntifungalsThe mechanism of action usually involves inhibiting pathways (enzymes, substrates, transport) necessary for sterol/cell membrane synthesis or altering the permeability of the cell membrane (polyenes) of the fungal cell. Clotrimazole (Lotrimin, Mycelex, Femizole-7, Gyne-Lotrimin)Imidazoles have broad-spectrum antifungal action and are used to treat dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. Inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells. Reevaluate diagnosis if no clinical improvement after 4 wk. Use 1% cream.
AdultAfter washing, gently massage into affected area and surrounding skin areas bid PediatricChildren: Not established
None reported
Documented hypersensitivity
PregnancyB - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals PrecautionsNot for treatment of systemic fungal infections; avoid contact with the eyes; if irritation or sensitivity develops, discontinue use and institute appropriate therapy AntimicrobialsThese agents tend to destroy microbes, to prevent their multiplication or growth, or to prevent their pathogenic action. Metronidazole (1% Noritate cream, 0.75% MetroGel cream or lotion)Imidazole with the ability to inhibit fungi, protozoa, and anaerobic bacteria. Anti-inflammatory effects include modulation of leukocyte activity.
AdultAfter washing, apply and rub a thin film on entire affected area qd/bid PediatricNot established
Deterrence/Prevention
Prognosis
Patient Education
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